Determine sampling interval from a process validation batch during compression

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Calculating sampling interval during compression from a process validation batch


Sampling Wave model




FIG: Sampling Wave


Output/min. = RPM * No. of station……………………….(1)
For example:
Given,
RPM (r) = 20
No. of station (N) = 27
Output/min. (O) = ?
0 = N * R
= 27 * 20
=  54O tablet/min

Sampling interval = Qty. of granules in tablet / Output per min. * No. of sample………………(2)
For example:
Given,
Qty. of granules in tablet (Q) = 100,000
Output per min. = 540 tablet/min
No. of sample (N) = 100
Sampling interval (SI) = ?
SI = Q/0 *  N
= 100,000/540 * 100




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