Disinfectants & Microbial Resistance

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Microbes grow resistance from disinfectants:
Resistance in microbes against disinfectants for cleaning purpose is a dangerous issue in pharmaceuticals but the maximum of the pharmaceuticals operation units it is ignored. Continuous application of same disinfectants may lead to the development of resistance in the microbes.




Fig: Pharmaceutical Floor Cleaning.

How microbes developed resistance:
Usually, we evaluate disinfectants for their efficacy using normal microbars but we do not use resistance strains. That’s why, it is important to concentrate on the development of resistance in our environment isolates against our cleaning solutions.

Most of the microbes develop defense mechanism against the disinfectant solutions. Pathogenic bacteria such as: staphylococcus aureus develops some protein those helps to pump out the toxins from the cell to protect itself.

Major cause of the development of resistance is use of low concentration of the disinfectant for cleaning the floor. Some pharmaceuticals manufacturers use less concentrate disinfection solutions than recommended by the manufacturer. This will not kill all of microbes present on floor.

Only week microbes are killed and strong remain alive. After repeated use of this disinfectant the population of these strong or resistance microbes will increase and the situation can be dangerous for the products manufactured in the facility. These microbes contaminate the products during the manufacturing and packaging. Disinfectant used purpose should be changed weekly. This will also happen upon use of the same disinfectant solution for a long period. 

When we use same disinfectant for a long time it will help to increase the population of resistant microbes. But when we use two or more disinfectants, microbes resistant against one have different active agent. Sometimes it is seen that companies are using different brands of disinfectants but they have same active agent.

It must be checked after a time interval that all microbes are being killed by the disinfectants. Floor should be cleaned by the disinfectant and sample is taken by swab or contact solutions. It should be implemented in all manufacturing facilities to identify the resistant microbes.

Location: Dhaka, Bangladesh

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