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Pharmaceuticals Manufacturing Technology

Writer: Shayne Cox Gad
A Johnley & Sons Inc. Publication



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Cleaning Validation | Campaign Cleaning Validation (CCV)

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When the product demand does not allow for a complete clean up after each batch, a campaign cleaning validation must be conducted.   A back to back cleaning is performed between batches in a campaign, and a complete cleaning at the end of a campaign. Sampling of the equipment is performed after the last batch in a campaign, and all test results must meet predetermined acceptance criteria as per campaign cleaning validation protocol.   Samples for residual active may be taken after back to back cleanings where possible, for information only . Microbiology samples may be taken after back to back cleanings in a campaign to ensure that there is no excessive microbial growth on the equipment.
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Bradford Protein Assay for determining protein concentration

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Western blot | Re-use a primary antibody

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